Characterization of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced modification of hepatic pyruvate carboxylase gene expression in C57BL/6J male mice by Barney R. Sparrow

Cover of: Characterization of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced modification of hepatic pyruvate carboxylase gene expression in C57BL/6J male mice | Barney R. Sparrow

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  • Tetrachlorodibenzodioxin.,
  • Pyruvate carboxylase.,
  • Mice -- Genetics.,
  • Genetic toxicology.

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Statementby Barney R. Sparrow.
The Physical Object
Pagination226 leaves, bound :
Number of Pages226
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Open LibraryOL18100428M

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action. Safe S(1), Astroff B, Harris M, Zacharewski T, Cited by: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is formed as an unintentional by-product of incomplete combustion.

It may be released to the environment during the combustion of fossil fuels and wood, and during the incineration of municipal and industrial wastes.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a polychlorinated dibenzo-p-dioxin (sometimes shortened, though inaccurately, to simply 'dioxin') with the chemical formula C12 H 4 Cl 4 O TCDD is a colorless solid with no distinguishable odor at room temperature.

It is usually formed as an unwanted product in burning processes of organic materials or as a side product in organic al formula: C₁₂H₄Cl₄O₂. Part III: Integrated Summary and Risk Characterization for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds Full Document (Table of Contents.

INTRODUCTION 1 This document presents an integrated summary of available information related to 2 exposure to and possible health effects of dioxin and related compounds.

It also presents a short 3 risk characterization, which is a concise statement of dioxin science and the public health 4 implications of both general population exposures from environmental “background”1 and.

Symbol which looks like a small house Solid circle with an upward pointer in it. Jump to content. 2,3,7,8-Tetrachlorodibenzo-p-dioxin CAS No. Known to be a human carcinogen First listed in the Second Annual Report on Carcinogens () Also known as dioxin, TCDD, or 2,3,7,8-TCDD O O Cl Cl Cl Cl Carcinogenicity 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to be a human carcinogen based on sufficient evidence of File Size: KB.

2,3,7,8-Tetrachlorodibenzo-p-dioxin and related compounds. CAS Number Synonym(s) Dioxin, TCDD. Occurence(s)/Use(s) Byproduct of manufacture of chlorophenols, hexachlorophene, and herbicides; contaminant of the Agent Orange, PCBs, and pentachlorophenol; component of combustion, including waste incineration and tobacco smoke.

Synonyms for 2,3,7,8-tetrachlorodibenzo-p-dioxin in Free Thesaurus. Antonyms for 2,3,7,8-tetrachlorodibenzo-p-dioxin. 2 words related to dioxin: Agent Orange, hydrocarbon. What are synonyms for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Characterizing the role of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP) in estrogen receptor signalling Susanna Shu Xian Tan Master of Science Department of Pharmacology and Toxicology Characterization of Tiparp -/-mice Author: Susanna Shu Characterization of 2,3,7,8-tetrachlorodibenzo-p-dioxin book Tan.

Previous studies have demonstrated that repeated (14 day) administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) enhances the suppression of humoral immunity in DBA/2 (Ah-low responder) mice relative to the effect seen with identical cumulative doses after a single treatment (cumulative doses of, and 42 mg/kg).

In the present studies, we have explored this Cited by: 2,3,7,8 - Tetrachlorodibenzo-p-dioxin Changes chemically when exposed in isooctane or n-octanol to UV light tetrachlorodibenzo-p-dioxin is stable under ordinary conditions of storage. 2,3,7,8-TCDD is considered relatively stable toward heat, acids, Chemical Stability 4.

REACTIVITY DATA: 2,3,7,8 - Tetrachlorodibenzo-p-dioxin Page 1 of 3. Search results for 2,3,7,8-Tetrachlorodibenzo-p-dioxin at Sigma-Aldrich. Compare Products: Select up to 4 products.

*Please select more than one item to compare. The most potent of these compounds is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic contaminant produced by various industrial processes [15, 16]. TCDD-induced toxicity is largely mediated through the Characterization of 2,3,7,8-tetrachlorodibenzo-p-dioxin book aryl hydrocarbon receptor (AhR) which is present in all vertebrates [ 17 ].Cited by: 8.

Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a widespread highly toxic environmental contaminant, suppresses immune response and leads to an increased susceptibility to infectious particular, several studies have provided evidence that TCDD decreases resistance to numerous by: 4.

United States Environmental Protection Agency Office of Research and Development, Washington D& EPA//P/Ag June External Review Draft vvEPA Review Draft (Do Not Exposure and Human C'*e or Health Reassessment 0fQuote' 2,3,7,8-Tetrachlorodibenzo- p-Dioxin (TCDD) and Related Compounds Part III: Integrated Summary and Risk Characterization for 2,3,7,8.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. ) is a colorless to white crystalline solid, which is the most toxic of a class of 75 structurally related congeners called chlorinated Author: Robert Kapp. Supporting Documents for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments, Volume 1.

Chemically, dioxin is also called 2,3,7,8 – Tetrachlorodibenzo-p-dioxin (TCDD). Its Chemical Abstracts Service (CAS) number isthe UN number given isand the chemical formula is.

On the physical side, to be melted, dioxin should have the melting point ranged from to since it is an organic white crystals or crystalline. Define 2,3,7,8-tetrachlorodibenzo-p-dioxin. 2,3,7,8-tetrachlorodibenzo-p-dioxin synonyms, 2,3,7,8-tetrachlorodibenzo-p-dioxin pronunciation, 2,3,7,8-tetrachlorodibenzo-p-dioxin translation, English dictionary definition of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Any of several carcinogenic, mutagenic, and teratogenic polychlorinated. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) ALS Environmental may or may not test for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS # ).

Information is subject to change; please contact us for the latest available analytes for which we test. Neurotoxic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) has not been fully elucidated, despite the known potent agonist of arylhydrocarbon receptor (AhR), which activation induces cytochrome P 1A and several representative toxicities of halogenated aromatic the present study, the effects of TCDD on cell death in zebrafish embryos (Danio rerio) during the early Cited by:   2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and 1,2,3,6,7,8- and 1,2,3,7,8,9-hexachlorodibenzo-p-dioxins (HCDDs) are among the most toxic and carcinogenic of “man-made” chemicals.

These “dioxins,” as well as many of the other polychlorinated dibenzodioxins (PCDDs) and dibenzofuran (PCDFs) derivatives, are chlorinated aromatic compounds which are chemically stable, Cited by:   2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic man-made chemical compound contaminating the environment.

An exposure of living organisms to TCDD may result in numerous disorders, including. International Notes Preliminary Report: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure to Humans -- Seveso, Italy.

At approximately noon on Saturday, Jan explosion occurred during the production of 2,4,5-trichlorophenol in a factory in Meda, about. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Cl37 ALS Environmental may or may not test for 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Cl37 (CAS # ).

Information is subject to change; please contact us for the latest available analytes for which we test. °C Jean-Claude Bradley Open Melting Point Dataset °C LabNetwork LN °C Parchem – fine & specialty chemicals F ( °C) Wikidata Q F ( °C) Wikidata Q All mass spectra in this site (plus many more) are available from the NIST/EPA/NIH Mass Spectral Library.

Please see the following for information about the library and its accompanying search program. of 2,3,7,8-tetrachlorodibenzo-p-dioxin (hereafter referred to as TCDD), and similar chemicals, to human health and the environment. SinceEPA has classified and aspects of risk characterization to exemplify approaches and applicability of current information.

The resulting analyses have two uses. First, as discussed previously, analysis. An investigation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrachloro dibenzo-p-furan (TCDF) bioaccumulation in blue crabs and American lobsters collected from Newark Bay and the New York Bight revealed widespread contamination across the continental shelf.

Separate analyses of muscleFile Size: 1MB. The one with four chlorine atoms at positions 2, 3, 7 and 8 of the dibenzo-p- dioxin chemical structure is called 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD).

It is a colorless solid with no known odor. 2,3,TCDD does not occur naturally nor is it intentionally manufactured by any industry, except as a reference standard. (OSF) for 2,3,7,8 -Tetrachlorodibenzo-p-dioxin (TCDD) Glenn Rice, Sc.D.

National Center for Environmental Assessment. Office of Research and Development. Science Advisory Board Dioxin Review Panel Meeting. Washington, DC.

Octo Office of Research and Development National Center for Environmental AssessmentFile Size: KB. 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) reaacts when exposed to ultraviolet light in solution in isooctane or n-octanol.

Undergoes catalytic perchlorination (NTP, ). Belongs to the Following Reactive Group(s). Exposure of fish larvae to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a reduction in peripheral circulation, edema, craniofacial malformation, and growth retardation, and culminating in mortality (Elonen et al., ; Henry et al., ; Walker and Peterson, ).These signs of toxicity are essentially identical to blue sac disease in rainbow trout larvae (Spitsbergen et al., ) and Cited by: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) More information about 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related compounds.

Chemical Status; Cancer: Currently listed. Reproductive Toxicity: Currently listed. Chemical Listing Details. Cancer; Listed as. Between the yearsthe mean concn of 1,2,3,7,8,9-hexachlorodibenzo-p-dioxin was 17 pg/g lipid (N=40; range, pg/g lipid) in the adipose tissue of British Columbia residents who had elective abdominal surgery(3).

1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin was found in blood from the general population of Germany at a mean concn of 7. Cork stoppers for wine bottles contained 2,3,7,8-tetrachlorodibenzofuran at concns from to 7 ng/kg (n=4) while cork wallpaper contained this compound at 45 ng/kg(3).

2,3,7,8-Tetrachlorodibenzofuran was measured in different synthetic materials at concns of. American Chemical Society: Chemistry for Life. In the s and s, you could hardly open an issue of Chemical & Engineering News without finding an article on 2,3,7,8-tetrachlorodibenzo-p-dioxin, usually abbreviated as “dioxin” or “TCDD”.This compound and similar polychlorinated dibenzodioxins, are contaminants of the defoliant Agent Orange, which was used by U.S.

forces to combat. Abstract. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on regional red blood cell (RBC) perfusion rate, as an index of blood flow, and lower jaw development were investigated quantitatively in zebrafish embryos (Danio rerio) during early revealed by observation of live embryos and alcian-blue staining, TCDD retarded lower jaw development in a Cited by: Media in category "2,3,7,8-tetrachlorodibenzo-p-dioxin" The following 18 files are in this category, out of 18 total.

Although the committee reviewed all three parts of the Reassessment, it focused primarily on Part III— Dioxin: Integrated Summary and Risk Characterization for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds, as directed by the study charge.

The committee also considered new peer-reviewed studies published since Part III of.SUBSTANCE PROFILES REPORT ON CARCINOGENS,ELEVENTH EDITION 2,3,7,8-Tetrachlorodibenzo-p-Dioxin(TCDD); “Dioxin” CAS No.

Known to be a human carcinogen First Listed in the Second Annual Report on Carcinogens () Carcinogenicity 2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD or TCDD) isknown to be a human carcinogenbased on .The estimation of elimination rates of persistent compounds: a re-analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in Vietnam veterans.

Chemosphere 37(): It it useful to note that TCDD levels are strongly influenced by the age distribution of the population tested. 27 A Study of 2,3,7,8-Tetrachlorodibenzo-p-dioxin February

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